Chirimwa che cannabis chine anopfuura zana nemakumi maviri e phytocannabinoids uye anokwira mazana mashanu+ terpenes ayo ese anoita seane mhedzisiro, kwete chete pamuviri, asi pane mumwe nemumwe. Iyi synergistic mhedzisiro yavanoita kune mumwe nemumwe yakanzi the entourage effect.
Nevakawanda vanozvishandisa CBD ivo pachavo vachipawo kumbwa dzavo, katsi, uye dzimwe mhuka dzinovaraidza kuti dzibatsirwe nezvese kubva. kuderedza kushushikana kutsigira hutano hwese, zvakafanira kudzidza nezve ins uye kunze kweiyo etourage maitiro. Nekuita izvi, unogona kuita kuti zvigadzirwa zveCBD zvishande zvirinani kwauri iwe nemhuka dzako dzinovaraidza.
Zviri Mukati
Maitiro eCannabis Cannabinoids uye Terpenes Anoshanda Pamwe Chete
Kuti tinzwisise kuti cannabinoids uye terpenes zvinoshanda sei pamwe chete kugadzira iyo yekukurudzira mhedzisiro, isu tinofanirwa kutarisa kune yekudzora sisitimu inonzi endocannabinoid system (ECS).
Inoumbwa ne cell receptors uye neurotransmitters inovatarisa, ichiudza sero iro kuenzanisa chiito chekuita, iyo ECS yakakosha kune hutano uye kurarama. Semuenzaniso, iyo ECS inogona kubatsira kudzikama kuzvimba kana immune system yaremerwa uye ichiburitsa akawanda akawandisa ekuzvimba.
Mamwe masisitimu ECS ane basa rakakosha mukutsigira anosanganisira:
- Kudzidza uye ndangariro
- Emotional processing
- hope
- Kuderedza kupisa
- Kudzora marwadzo
- Kuzvimba uye immune mhinduro
- Kudya uye kuda kudya
Cannabinoids uye terpenes zvinopesvedzera mhedzisiro yeumwe neumwe paECS uye zvimwe zvakakosha zvinogamuchira, senge serotonin receptors, munzira dzinoverengeka.
Iyo Entourage Mhedzisiro: Muenzaniso 1
Imwe yenzira huru phytocompounds inofurirana nekusunga kune zvinogamuchira imwe komisheni isati yagona. Izvi zvinogona kuvhara iyo cannabinoid kana terpene zvachose, ichibvumira kuti iende kunotsvaga isina kusungwa receptors. Zvakare, ivo vanogona kukonzera kuvharika kwechikamu, kudzivirira imwe phytocompound kubva pakusunga zvizere kune receptor.
Uyezve, cannabinoids uye terpenes vese vanopikisa uye vanopikisa pane akasiyana mareceptor. An agonist anozomutsa ma receptors uye anogona kuvharira mamwe makomisheni kubva pakusunga nekuda kwavo nekutora anosunga mavara.
Anopikisa anoenda mberi, zvisinei. Haisi chete inogona kubvisa inosunga nzvimbo kubva kune imwe cannabinoid, asi inogona kudzivirira iyo receptor kubva pakuvhurwa kunyangwe paine anosunga mavara aripo.
Iyo Entourage Mhedzisiro: Muenzaniso 2
Macompounds ari mu cannabis, kunyanya terpenes, akawanikwa achipesvedzera ropa-brain barriers nekuderedza kuramba uye kudzoreredza permeability. Izvi zvinobatsira cannabinoids senge cannabidiol (CBD) kuti ipfuure zviri nyore, zvichikonzera kuderera kwedosi uye hukuru hukuru uye potency yemhedzisiro.
Semuyenzaniso, cannabinoids haidi kupfuudza iyo yeropa-brain chipingamupinyi kuvhura yavo analgesic zvivakwa, asi ivo vanonyanya kuita kana isu tichida yavo antinociceptive mhedzisiro pamusoro. Antinociceptives zvinhu zvinovhara marwadzo zviratidzo pamatanho akasiyana-siyana munzira yekurwadziwa, nepo analgesics inoshandura maonero ekurwadziwa.
The Entourage Effect Controversy
Nepo tsvagiridzo yakawana humbowo hweiyo cannabis makomisheni anoshanda pamwechete, a 2020 kuongorora yakasundidzira kumashure pfungwa yekuti mhedzisiro inogara iri chinhu chakanaka.
Vanyori veongororo inocherekedza kuti pane musiyano mukuru pakati pekutsvagisa kushoma pamusoro pekuti mhedzisiro inoburitsa nekuvimbika mibairo inobatsira uye vagadziri veCBD vanoigamuchira nemoyo wese, kunyanya kana vachitengesa zvigadzirwa zvavo.
Nekuda kwekuve nemakomisheni akawanda, mazhinji ayo anoonekwa mune zviteedzere asi achiri kuita kunge ane pesvedzero, zvakaoma zvikuru kuona kuti ndeapi cannabinoids uye terpenes anoshanda pamwe chete uye nechiyero chipi.
Nemakomboni akawanda iwayo, huwandu hwemisanganiswa yatinogona kugadzira ndeyemuchadenga, uye hazvitombotarise kuve nemakomboni acho achionekwa muhuwandu hwakasiyana (concentrations).
Zvisinei, zvinoratidzika kuti cannabinoid inotsaura kazhinji inoburitsa mhedzisiro isina kuenzana. Semuyenzaniso, THC yakazvitsaura ndiyo inokonzeresa paranoia, nekuti hapana mamwe cannabinoids anokanganisa kugona kweTHC kuwedzeredza CB1 receptors.
Nepo zvekuzviparadzanisa zvinongove neCBD zvinoda yakakwira kupfuura yakajairwa madosi uye zvine mashoma mhedzisiro zvichienzaniswa neakazara spectrum CBD zvigadzirwa.
Ndechipi Chigadzirwa cheCBD chine Iyo Yakanakisa Entourage Mhedzisiro?
Paunenge uchitsvaga iyo yakazara yakazara etourage mhedzisiro, yakazara spectrum CBD zvigadzirwa zvinowanzove zvakanakisa, sezvo zvine ese cannabinoids uye terpenes chirimwa che cannabis chinofanira kupa.
Kukurudzira A Positive Entourage Effect
Kunyange zvazvo takadzidza kuti chiitiko chekukurudzira chiitiko chaicho, takadzidzawo kuti hatifaniri kugara tichienzanisa nemabhenefiti akanaka.
Nekudaro, nekuyedza kudiki, unogona kuenda kure mukuona kuti inogara ichiburitsa zvakanakisa. Uye iwe unogona kuzviita nekusanganisa uye kuenzanisa zvigadzirwa zve cannabis pamwechete.
Kunze kwekunge iwe kana chipfuyo chako chine sensitivity kune THC - vazhinji havadaro - yakazara spectrum CBD ndiyo yakanakisa CBD chigadzirwa chekutanga. Uye kunyangwe mushure, ichiri kupa hwaro hwakanaka.
Kana zvasvika kuvanhu, nhanho inotevera ine musoro kuwedzera THC yekuzviparadzanisa kana yakazara spectrum THC chigadzirwa mumusanganiswa. Nekuti nepo THC ichinyanya kuita basa rekupa mbanje zvirimwa kugona kwavo kukonzera yakakwirira, inorapa zvakanyanya.
Iwo cannabinoids, kunyanya, CBD, inoshanda nemazvo kuvharira THC kubva pakuwedzeredza yakawandisa ma receptors, kudonhedza kana kubvisa iyo yakakwira, asi iyo THC yaunowedzera kuCBD yako, ndipo zvakanyanya mhedzisiro inofanana nemhedzisiro yembanje.
Kana iwe uchida kudzivirira iyo yakakwirira kana kuti uchida kuvandudza CBD yakazara spectrum mhedzisiro yemhuka yako, CBD yekuzviparadzanisa nevamwe inoshanda zvikuru. CBG uye CBN zvigadzirwa dziri kuve dzakakurumbira uye dzinogona kushanda sekuwedzera kwakanakisa,
asi kungwarira kunorayirwa. Nokuti nguva CBG uye CBN haisi psychoactive mupfungwa imwechete se THC, kureva, hazvikonzeri euphoric yakakwirira, ivo vane psychoactive kupfuura CBD nekuda kweavo activating receptors muuropi.
Anecdotally, vazhinji vanoti CBG inonzwa senge caffeine yekumhanyisa uye inoita kuti vanzwe kushamwaridzana, nepo CBN ichikurudzira kuzorora kwakanyanya uye sedation.
Kiyi Yekutora
Paunenge uchitsvaga iyo yakanyanya kukurudzira mhedzisiro, yakazara spectrum CBD ndiyo yekuenda. Nekudaro, kushandisa zvimwe zvigadzirwa zve cannabis mu tandem inzira huru yekugadziridza iyo yekukurudzira maitiro kune zvaunoda. Saka usatya kuedza, ingoita shuwa kuti uri kutanga waita tsvagiridzo yako.
